melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
About Us
Our Services
HIGH THROUGHPUT IN VIVO PHARMACOLOGY:
DISCOVERY SERVICES:
Our Technology
Partnering with Us
Press & Publications
Contact Us
melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Our Services in vivo efficacy models


Focused Disease Efficacy Models

In addition to the theraTRACE® indications discovery platform and a proprietary Alzheimer’s disease model, Melior is able to extend its high throughput pharmacology approach to customized in vivo efficacy evaluations in other focused therapeutic areas.

Melior has established expertise in the following major therapeutic areas:

OBESITY

Diet-Induced Obesity

ob/ob-mouse Model

db/db-mouse Model

Zucker Rat Model

Cold-Sensitivity with Telemetry

PSYCHOTHERAPEUTIC AND NEUROLOGY

Tail Suspension

Forced Swim

Stress-Induced Corticosterone

Irwin Battery of Tests

Open-Field Locomotor Activity

PTZ Induced Seizure

Audiogenic Seizure

Fear Conditioning

Novel Object Recognition

Startle Pre-Pulse Inhibition

Maximal Electroshock Seizure

Chronic Mild Stress

Vogel Water Conflict

Light Dark Transitions

Stress-Induced Hyperthermia

INFLAMMATION/IMMUNOLOGY

Collagen Induced Arthritis (CIA)

EAE Model of Multiple Sclerosis

LPS-Systematic Inflammation

Monocyte Infiltration

GASTROINTESTINAL

Colonic Propulsion

Stress-Induced Fecal Production

Morphine-Induced Constipation

Acetylcholine Writhing

Fecal Accumulation

Gastrointestinal Transit

UROGENITAL

Diuretic-Mediated Micturition

DIABETES

OGTT in Normoglycemic Mice

ob/ob-mouse Model

db/db-mouse Model

Zucker Rat Model

STZ-Induced Diabetes (type I model)

PAIN

Hot Plate

Formalin

Von Frey/Carrageenan

Neuropathic Pain

Tail Flick

NEURODEGENERATION

MPTP Model for Parkinson’s

APP/PS1 Gene Targeted Mice
(Alzheimer’s Model)

CARDIOVASCULAR

Bleeding Time

Tail Cuff

Cardiovascular Telemetry

DERMATOLOGY

Contact Dermatitis

Sebum Production

Hair Growth

ALLERGY/RESPIRATORY

Delayed Type Hypersensitivity (DTH)

Pulmonary Inflammation (ovalbumin)

Intranasal LPS Inflammation

OTHER

Testosterone

Clinical Chemistry

Blood Parameters

Home Cage Activity with Telemetry

IN VIVO MEASUREMENTS

Weight Gain

Food Intake

DEXA Analysis

Leptin

Adiponectin

Multiple cytokines

Glucose levels

Insulin

Multiple metabolic hormones

Aβ 1-42, 1-40 Levels
Histochemistry

Click here to download
our Models Brochure

Melior’s In Vivo Pharmacology Experience

Melior’s management has combined experience of more than 120 years in pharmacology and drug discovery applications and has evaluated more than 200 compounds for novel indications in just 3 years. The company has long-term collaborations with Pfizer, Merck, AstraZeneca and others.

Back to top of page
 
home