melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
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Melior Models brochure download Click here to download the Melior Brochure -
revised June 2010

theraTRACE

Melior Pharmaceuticals

 

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Our Services in vivo efficacy models

 
   

Focused Disease Efficacy Models

In addition to the theraTRACE® indications discovery platform and a proprietary Alzheimer’s disease model, Melior is able to extend its high throughput pharmacology approach to customized in vivo efficacy evaluations in other focused therapeutic areas.

Melior Discovery announces the availability of
individual pharmacology models.


Melior Discovery has pioneered a proprietary high-throughput in vivo pharmacology platform (theraTRACE®) successfully used by multinational pharmaceutical companies to profile preclinical drug candidates. In response to growing demands, we are now able to offer this same expertise applied to the design and execution of in vivo studies utilizing individual efficacy models.

Melior’s In Vivo Pharmacology Experience

Melior’s management has combined experience of more than 120 years in pharmacology and drug discovery applications and has evaluated more than 200 compounds for novel indications in just 3 years. The company has long-term collaborations with Pfizer, Merck, AstraZeneca and others.

OBESITY
Diet-Induced Obesity
ob/ob-mouse Model
db/db-mouse Model
Zucker Rat Model
Cold-Sensitivity with Telemetry

PSYCHOTHERAPEUTIC AND NEUROLOGY
Tail Suspension
Forced Swim
Stress-Induced Corticosterone
Irwin Battery of Tests
Open-Field Locomotor Activity
PTZ Induced Seizure
Audiogenic Seizure
Fear Conditioning
Novel Object Recognition
Startle Pre-Pulse Inhibition
Maximal Electroshock Seizure
Chronic Mild Stress
Vogel Water Conflict
Light Dark Transitions
Stress-Induced Hyperthermia

SLEEP/WAKE
Diurnal Home Cage Activity
Electroencephalography (EEG)/
Electromyography (EMG)


INFLAMMATION/IMMUNOLOGY
Collagen Induced Arthritis (CIA)
EAE Model of Multiple Sclerosis
LPS-Systematic Inflammation
Monocyte Infiltration


GASTROINTESTINAL
Colonic Propulsion
Stress-Induced Fecal Production
Morphine-Induced Constipation
Acetylcholine Writhing
Fecal Accumulation
Gastrointestinal Transit

UROGENITAL
Diuretic-Mediated Micturition

DIABETES
OGTT in Normoglycemic Mice
ob/ob-mouse Model
db/db-mouse Model
Zucker Rat Model
STZ-Induced Diabetes (type I model)

PAIN
Hot Plate
Formalin
Von Frey/Carrageenan
Neuropathic Pain
Tail Flick

NEURODEGENERATION
MPTP Model for Parkinson’s
APP/PS1 Gene Targeted Mice (Alzheimer’s Model)
Peripheral Nerve Conduction Velocity


CARDIOVASCULAR
Bleeding Time
Tail Cuff
Cardiovascular Telemetry

DERMATOLOGY
Contact Dermatitis
Sebum Production
Hair Growth

ALLERGY/RESPIRATORY
Delayed Type Hypersensitivity (DTH)
Pulmonary Inflammation (ovalbumin)
Intranasal LPS Inflammation

OTHER
Testosterone
Clinical Chemistry
Blood Parameters
Home Cage Activity with Telemetry
Somatosensory Evoked Potential

IN VIVO MEASUREMENTS
Weight Gain
Food Intake
DEXA Analysis
Leptin
Adiponectin
Multiple Cytokines
Glucose Levels
Insulin
Multiple Metabolic Hormones
Aβ 1-42, 1-40 Levels
Histochemistry
In vivo Electrophysiology

Click here to download
our Models Brochure

 

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