Melior Discovery Publications

In-Vivo Phenotypic Screening: Clinical Proof of Concept for a Drug Repositioning Approach
Ciallella JR, Reaume, AG
Science Direct, Elsevier, March 2017

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Phenotypic Screening
Macolino-Kane CM, Ciallellla, JR,Lipinski CA, Reaume AG
In: Drug Repositioning: Approaches And Applications For Neurotherapeutics.  CRC Press, June 2017.  Ed. Dudely J, Berliocchi L.

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A Mouse Model of Furosemide-Induced Overactive Bladder
Saporito MS, Zuvich E, DiCamillo A
Curr Protoc Pharmacol 2016 Sep; 74:5 68, 1-5

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Rule of Five in 2015 and Beyond:  Target and Ligand Structural Limitations, Ligand Chemistry Structure and Drug Discovery Project Decisions
Christopher A. Lipinski
Science Direct, Elsevier, April 27, 2016

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Parallel Worlds of Public and Commercial Bioactive Chemistry Data
Lipinski CA, Litterman NK, Southan C, Williams AJ, Clark AM and Ekins S.
J. Med. Chem. 2014 Nov; Article ASAP.

Computational Prediction and Validation of an Expert’s Evaluation of Chemical Probes
Litterman NK, Lipinski CA, Bunin BA, Ekins S.
J. Chem. Inf. Model., 2014 Sept; 54(10): 2996-3004.

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The future of drug discovery: Two required supplements to current practices.
Reaume AG, Lipinski CA.
Pharma July 2013

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MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in-vivo.
Saporito MS, Ochman AR, Lipinski CA, Handler JA, Reaume AG.
J Pharmacol Exp Ther. 2012 Jul;342(1):15-22.

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The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.
Ochman AR, Lipinski CA, Handler JA, Reaume AG, Saporito MS.
J Pharmacol Exp Ther. 2012 Jul;342(1):23-32.

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Phenotypic in-vivo screening to identify new unpredicted indication for existing drugs and drug candidates.
Saporito MS, Lipinski CA, Reaume AG
in Drug Repositioning: Bringing New Life to Shelved Assets. (John Wiley & Sons, Hoboken, NJ, USA) 2012. Barratt MD and Frail D (Eds).

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Drug repurposing through nonhypothesis driven phenotypic screening.
Reaume AG.
Drug Disc. Today 2011 8(3-4):85-88.

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theraTRACE®: A mechanism unbiased in-vivo platform for phenotypic screening and drug repositioning.
Saporito MS, Reaume AG.
Drug Disc. Today 2011 8(3-4):89-95.

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The anti-intellectual effects of intellectual property.
Lipinski CA.
Curr Opin Chem Biol. 2006 Aug;10(4):380-3.

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