In Vivo Disease Models
Capture the untapped value of therapeutics with our in vivo Pharmacology Platforms
Melior’s suite of in vivo pharmacology services includes a wide array of in vivo models with broad therapeutic coverage. These include more than eighty validated animal models (both in vivo rat models and in vivo mouse models) across fourteen therapeutic areas. But, these are just our core models. Many of the studies that Melior runs for clients involve customized models or modifications of existing models.
Therapeutic Areas
Cardiovascular
Gastrointestinal
- Colonic Propulsive Motility
- DSS-Induced Colitis
- Gastrointestinal Transit
- IBS and Acetylcholine Writhing
- Morphine – Induced Constipation
Hair Growth & Dermatitis
Inflammation & Arthritis
Arthritis Models
Inflammation Models
- Acute Nephritis
- Acute Pancreatitis
- EAE Model of Multiple Sclerosis
- Monocyte Infiltration
- LPS – Systemic Inflammation
- LPS – Pulmonary Inflammation
- Pulmonary Allergic Asthma
- Zymosan – A Induced Acute Peritonitis
Sensitivity Models
- Allergic Contact Hypersensitivity
- Capsaicin Hyperalgesia
- Delayed Type Hypersensitivity
- Formalin Analgesia
Metabolic
Diabetes
- db/db Mouse Model of Type II Diabetes
- ob/ob Mouse Model of Type II Diabetes
- Streptozotocin-Induced Type I Diabetic Rat Model
Insulin Sensitivity Models
NASH / NAFLD
Obesity Models
Motor Function
Neurology
Epilepsy and Seizure Models
- 6-Hz Psychomotor Seizure
- Audiogenic Seizure in Fmr1 Knockout Mice
- EEG Pro- and Anti-Convulsant Evaluation
- Lithium Pilocarpine Status Epilepticus
- Maximal Electroshock (MES)
- Pentylenetetrazole-Induced Seizure (PTZ)
Multiple Sclerosis Models
Parkinson’s Disease Models
Sensorimotor Assays
Neurophysiology
Electroencephalogram Frequency Analysis (qEEG)
Event Related Potentials
Reflex Response
Single Unit Recording
Pain
Algesia Models
Neuropathic Pain Models
- Chronic Constrictive Injury
- Diabetic Neuropathy Model
- IBS and Acetylcholine Writhing
- Migraine Headache
- Spinal Nerve Ligation
- von Frey / Carrageenan Allodynia Assay
Psychiatric & Cognitive
Anxiety Models
Chronic Mild Stress Model
Depression Models
Learning and Memory Evaluation
Sensorimotor Models
Pulmonary
Tissue Repair
Urogenital
General & Safety Pharmacology
Drug Abuse & Addiction Models
- Conditioned Place Preference
- Drug Discrimination
- Locomotor Sensitization
- Self-Administration
- Withdrawal & Dependence
General Assessment
Pharmacokinetics / Pharmacodynamics
Seizure Potential
If you have any additional questions, please don’t hesitate to contact us at bizdev@meliordiscovery.com to start the conversation.