In Vivo Disease Models
Capture the untapped value of therapeutics with our in vivo Pharmacology Platforms
Melior’s suite of in vivo pharmacology services includes a wide array of in vivo models with broad therapeutic coverage. These include more than eighty validated animal models (both rat in vivo models and mouse in vivo models) across fourteen therapeutic areas. But, these are just our core models. Many of the studies that Melior runs for clients involve customized models or modifications of existing models. Please contact us if you want to work with Melior to develop a customized in vivo disease model or replicate something from the literature that is not generally available in other CROs.
Therapeutic Areas
Cardiovascular
Gastrointestinal
- Colonic Propulsive Motility
- DSS-Induced Colitis
- Fecal Pellet Output
- Gastrointestinal Transit
- IBS and Acetylcholine Writhing
- Morphine – Induced Constipation
Hair Growth & Dermatitis
Inflammation & Arthritis
Arthritis Models
Inflammation Models
- Acute Nephritis
- Acute Pancreatitis
- EAE Model of Multiple Sclerosis
- Monocyte Infiltration
- LPS – Systemic Inflammation
- LPS – Pulmonary Inflammation
- Pulmonary Allergic Asthma
- Zymosan – A Induced Acute Peritonitis
Sensitivity Models
- Allergic Contact Hypersensitivity
- Capsaicin Hyperalgesia
- Delayed Type Hypersensitivity
- Formalin Analgesia
Metabolic
Diabetes
- db/db Mouse Model of Type II Diabetes
- ob/ob Mouse Model of Type II Diabetes
- Streptozotocin Induced Type I Diabetic Model
Insulin Sensitivity Models
NASH / NAFLD
Obesity Models
- DEXA Body Composition Scan
- Diet – Induced Obesity
- Western Diet – Induced Obesity and Hyperleptinemia
- Food Intake
Motor Function
- Grip Strength
- Harmaline-Induced Tremor
- Open Field Activity
- Motor Evoked Potentials
- Pole Test
- Rotarod
Neurology
Epilepsy and Seizure Models
- 6-Hz Psychomotor Seizure
- Audiogenic Seizure in Fmr1 Knockout Mice
- EEG Pro- and Anti-Convulsant Evaluation
- Lithium Pilocarpine Status Epilepticus
- Maximal Electroshock (MES)
- Pentylenetetrazole-Induced Seizure (PTZ)
Multiple Sclerosis Models
Parkinson’s Disease Models
- 6-OHDA Lesion in Rat
- Haloperidol-Induced Catalepsy
- L-DOPA-Induced Dyskinesia
- MPTP-Induced Mouse Model
Sensorimotor Assays
Neurophysiology
Electroencephalogram Frequency Analysis (qEEG)
Event Related Potentials
Reflex Response
Single Unit Recording
Pain
Algesia Models
- Capsaicin Hyperalgesia
- Formalin Analgesia
- Hargreaves Hyperalgesia
- Hot Plate
- Tail Flick
- Tail Immersion
Neuropathic Pain Models
- Chemotherapy-Induced Neuropathy
- Chronic Constrictive Injury
- Diabetic Neuropathy Model
- IBS and Acetylcholine Writhing
- Migraine – Oshinsky Model
- Migraine – Inflammatory Cocktail
- Spinal Nerve Ligation
- von Frey / Carrageenan Allodynia Assay
Psychiatric & Cognitive
Anxiety Models
Chronic Mild Stress Model
Depression Models
Learning and Memory Evaluation
Sensorimotor Models
Pulmonary
- LPS – Pulmonary Inflammation
- Pulmonary Allergic Asthma
- Pulmonary Edema
- Pulmonary Fibrosis
- Respiratory Depression
Tissue Repair
Urogenital
General & Safety Pharmacology
Drug Abuse & Addiction Models
- Conditioned Place Preference
- Drug Discrimination
- Locomotor Sensitization
- Self-Administration
- Withdrawal & Dependence
General Assessment
Pharmacokinetics / Pharmacodynamics
Seizure Potential
If you did not find the in vivo disease model that you are looking for or if you have any additional questions, please don’t hesitate to contact us at bizdev@meliordiscovery.com to start the conversation.
