In vivo Efficacy Models

In Vivo Disease Models

Melior’s suite of in vivo pharmacology services includes a wide array of in vivo models with broad therapeutic coverage. These include more than eighty validated animal models (both rat in vivo models and mouse in vivo models) across fourteen therapeutic areas.

But, these are just our core models. Many of the studies that Melior runs for clients involve customized models or modifications of existing models. Please contact us if you want to work with Melior to develop a customized in vivo disease model or replicate something from the literature that is not generally available in other CROs.

Therapeutic Areas

Aging

Aging Mouse Models

Cardiovascular

Gastrointestinal

Hair Growth & Dermatitis

Infectious Disease

Inflammation & Arthritis

Arthritis Models

Collagen – Induced Arthritis

Inflammation Models

Sensitivity Models

Metabolic

Diabetes

Insulin Sensitivity Models

NASH / NAFLD

Obesity Models

Motor Function

Neurology

Epilepsy and Seizure Models

Multiple Sclerosis Models

Parkinson’s Disease Models

Sensorimotor Assays

Startle Prepulse Inhibition (PPI)

Neurophysiology

Electroencephalogram Frequency Analysis (qEEG)

Event Related Potentials

Reflex Response

Single Unit Recording

Subthalamic Nucleus (STN) Recording In Vivo

Oncology

Pain

Algesia Models

Neuropathic Pain Models

Psychiatric & Cognitive

Anxiety Models

Chronic Mild Stress Model

Depression Models

Tail Suspension

Learning and Memory Evaluation

Sensorimotor Models

Pulmonary

Tissue Repair

Urogenital

Micturition, Overactive Bladder,Urinary

General & Safety Pharmacology

Drug Abuse & Addiction Models

General Assessment

Pharmacokinetics / Pharmacodynamics

Seizure Potential

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If you did not find the in vivo disease model that you are looking for or if you have any additional questions, please don’t hesitate to contact us at [email protected] to start the conversation.

We chose Melior Discovery because they were responsive and cost effective. We are staying with them as a chosen scientific partner because of their thoughtful scientific input to experimental design and attention to detail. Their expertise and flexibility allowed us to quickly adapt the study design and evaluate additional outcome measures to pursue unexpected activity.
Sridharan Rajamani, Ph.D., Senior Research Scientist
Gilead Sciences
I have been working with Melior on a number of projects over the course of a few years now. They have been a great partner throughout this time. The scientists whom I have worked with have been great problem-solvers and were customer focused.
Jay Lichter
Avalon Ventures
Melior provided State-of-the-art Preclinical Pharmacology Support for a period of nearly a year where a series of in vivo studies were completed on a weekly basis. The staff was extremely user-friendly and the operational processes were excellent. I can recommend Melior without reservation.
Richard DiMarchi, PhD
Cox Professor of Chemistry & Gill Chair in Biomolecular Sciences Indiana University, Department of Chemistry
Because Melior could do the orthotopic intracranial implants, we were able to do survival studies with brain tumor-bearing animals that were treated with our therapy, showing a beautiful survival with our agent versus control. Talk about something that gets your investors going! These beautiful survival curves with our agent versus control and visual photos are in all of our investor decks because… it's powerful.
Bruce Ruggeri, Ph.D.
Modifi Bio
Melior works in many therapeutic areas, like CNS, inflammatory disease, GI, cardiovascular, and oncology. I was very pleased that when it came to doing tumor studies, both subcutaneous and intracranial, they did them well. They reported on the studies on time and did the data analysis really well.
Bruce Ruggeri, Ph.D.
Modifi Bio
Their areas of expertise are extensive, and they are very experienced, responsive, and flexible in terms of how the study is run. Their pricing is reasonable, making them the best option for a young, not well-funded company like ours.
Maxine Gowen
Tamuro Bio
Melior’s team was very experienced and knowledgeable. They were always very open to suggestions and questions, spending a lot of time helping us feel comfortable with the study design. I would give them very high marks.
Maxine Gowen
Tamuro Bio
The most important factors in choosing to work with Melior were the fit between the tests they could run and our needs, as well as their tight budget and proximity. Melior was the best fit for our research goals.
Ira Spector
SFA Therapeutics