In Vivo Disease Models

Capture the untapped value of therapeutics with our in vivo Pharmacology Platforms

Melior’s suite of in vivo pharmacology services includes a wide array of in vivo models with broad therapeutic coverage. These include more than eighty validated animal models (both rat in vivo models and mouse in vivo models) across fourteen therapeutic areas. But, these are just our core models. Many of the studies that Melior runs for clients involve customized models or modifications of existing models. Please contact us if you want to work with Melior to develop a customized in vivo disease model or replicate something from the literature that is not generally available in other CROs.

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Therapeutic Areas

Cardiovascular

Gastrointestinal

Hair Growth & Dermatitis

Infectious Disease

Inflammation & Arthritis

Arthritis Models

Collagen – Induced Arthritis

Inflammation Models

Sensitivity Models

Metabolic

Diabetes

Insulin Sensitivity Models

NASH / NAFLD

Obesity Models

Motor Function

Neurology

Epilepsy and Seizure Models

Multiple Sclerosis Models

Parkinson’s Disease Models

Sensorimotor Assays

Startle Prepulse Inhibition (PPI)

Neurophysiology

Electroencephalogram Frequency Analysis (qEEG)

Event Related Potentials

Reflex Response

Single Unit Recording

Subthalamic Nucleus (STN) Recording In Vivo

Oncology

Pain

Algesia Models

Neuropathic Pain Models

Psychiatric & Cognitive

Anxiety Models

Chronic Mild Stress Model

Depression Models

Learning and Memory Evaluation

Sensorimotor Models

Pulmonary

Tissue Repair

Urogenital

Micturition, Overactive Bladder, Urinary

General & Safety Pharmacology

Drug Abuse & Addiction Models

General Assessment

Pharmacokinetics / Pharmacodynamics

Seizure Potential

If you did not find the in vivo disease model that you are looking for or if you have any additional questions, please don’t hesitate to contact us at bizdev@meliordiscovery.com to start the conversation.

We chose Melior Discovery because they were responsive and cost effective. We are staying with them as a chosen scientific partner because of their thoughtful scientific input to experimental design and attention to detail. Their expertise and flexibility allowed us to quickly adapt the study design and evaluate additional outcome measures to pursue unexpected activity.
Sridharan Rajamani, Ph.D., Senior Research Scientist
Gilead Sciences
I have been working with Melior on a number of projects over the course of a few years now. They have been a great partner throughout this time. The scientists whom I have worked with have been great problem-solvers and were customer focused
Jay Lichter
Avalon Ventures
[We] have been impressed with [Melior’s] ability to rapidly and effectively evaluate compounds in animal models…as we strive to identify compounds to ameliorate the devastating symptoms of Rett,
Monica Coenraads, Executive Director
Rett Syndrome Research Trust
Melior is more than just a service company. Their experienced staff guided us in our drug development efforts. We consider Melior an extension of our own research team.
Josh Schultz
Carolus Therapeutics
Addex Therapeutics has been collaborating with Melior Discovery for more than a year. The studies performed at Melior are always carefully planned and skilfully executed while the progress of the project is well-tracked and communicated to the customer. On several occasions, when testing our compounds in a new in vivo assay, we relied on Melior's scientists in their guidance and advice. We have been particularly pleased with a series of experiments involving assessment of compounds' profiles in the rat sleep/wake EEG. This approach, that has a translational relevance, offered a sensitive measure of a compound's efficacy and side-effects
Mikhail Kalinichev, Ph.D., Associate Research Director
Addex Therapeutics
Having worked with Melior quite extensively over the past several years, we find the team to be highly knowledgeable, responsive and adaptable to our needs. The overall process has been highly efficient and we are impressed by the quality of their reports
Christopher Prior, Ph.D., CEO,
PhaseBio Pharmaceuticals Inc.
…to evaluate our lead compound in an EEG-based sleep wake model. Melior’s very experienced team provided valuable insights and recommendations on study design, analysis and interpretation of the data. As a virtual company, Prexa relied on Melior to become an extension of our knowledge team and they met all our expectations
Pat Baskin and Ev Graham
Prexa Pharmaceuticals
State of-the-art Preclinical Pharmacology
Melior provided State-of-the-art Preclinical Pharmacology Support for a period of nearly a year where a series of in vivo studies were completed on a weekly basis. The staff was extremely user-friendly and the operational processes were excellent. I can recommend Melior without reservation.
Richard DiMarchi, PhD
Cox Professor of Chemistry & Gil Chair in Biomolecular Sciences Indiana University, Department of Chemistry

List of In Vivo
Models PDF