Migraine - Oshinsky Model
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Headache disorders consistently rank as one of the most prevalent neurological conditions globally, with migraine being one of the most disabling disorders.
Though the mechanism of migraine is complex and unresolved, one hypothesis states repeated activation of the trigeminal vascular system leads to long-term physiological changes. Clinical symptoms include trigeminal allodynia and sensitivity to nitrates, both resulting in pain. A rat model of this pathology has been described by Oshinsky et al (2012). Melior has established and validated the Oshinsky model as a clinically translatable migraine animal model.
The prostaglandin-induced migraine animal model generally takes at least 6 weeks to complete when factoring in baseline measurements that are performed prior to surgery. Once migraine has been established animals can be used for an additional 4-5 weeks. Therefore, it is possible to test multiple compounds, with a “washout” between compounds, using a given cohort of animals.
Oshinsky ML, Sanghvi MM, Maxwell CR, Gonzalez D, Spangenberg RJ, Cooper M, Silberstein SD. (2012). Spontaneous trigeminal allodynia in rats: a model of primary headache. Headache.52(9):1336-49.