Tail Flick Test
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Hyperalgesia is a condition of enhanced sensitivity to painful stimuli. The Tail Flick Test measures the latency to thermal pain response and effectiveness of analgesics.
A number of clinically approved pharmacological agents have been demonstrated to delay the onset of heat sensitivity upon exposure to heat including opioids and GABA potentiators.
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The Tail Flick Test is typically run in an acute mode (study completed in one day) by evaluating test articles after a single administration. The variability is relatively low and statistical significance may be achieved with group sizes of about 8 to 10 animals. It can be performed in both mice and rats. Since it is non-invasive it can be easily incorporated several times over the course of a chronic study.