Tail Flick Test
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Hyperalgesia is a condition of enhanced sensitivity to painful stimuli. The tail flick assay measures the latency to thermal pain response and effectiveness of analgesics.
A number of clinically approved pharmacological agents have been demonstrated to delay the onset of heat sensitivity upon exposure to heat including opioids and GABA potentiators.
The Tail Flick assay is typically run in an acute mode (study completed in one day) by evaluating test articles after a single administration. The variability is relatively low and statistical significance may be achieved with group sizes of about 8 to 10 animals. It can be performed in both mice and rats. Since it is non-invasive it can be easily incorporated several times over the course of a chronic study.