Hot Plate Test
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Hyperalgesia is a condition of enhanced sensitivity to painful stimuli. The thermal analgesia hot plate test is a pharmacological test for evaluating the analgesic potential of test compounds.
A number of clinically approved pharmacological agents have been demonstrated to delay the onset of heat sensitivity upon paw exposure to heat including opioids and GABA potentiators. Typically, the hot plate test is included in a battery of assays in evaluating the analgesic potential of test compounds.
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Frequently Asked Questions
Absolutely! Hot plate test is a great way to measure pain reactions to thermal stimuli. Determining if there is a response to mechanical stimuli using Von Frey could also give valuable information on a compound’s analgesic effects.
This test is often used in larger studies, such as a diabetic neuropathy or chemotherapy induced neuropathy study. Alternatively, it can be used in an inducible pain model, such as a capsaicin hyperalgesia model.
Synonyms: Pain, Analgesic