Chronic Constriction Injury
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Peripheral nerve injury, due to trauma, disease or various sources of toxicity is a cause of chronic pain. This pathology can be readily modeled in rodents with a number of neuropathic pain models that Melior has developed.
The chronic constriction injury (CCI) model is induced by ligation to the sciatic nerve. Melior has experience in developing several versions, including partial and complete sciatic nerve ligation models in rats. Signs of neuropathy typically become apparent within a week after surgery.
The CCI model induces a neuropathic pain response that can be detected by von Frey mechanical thresholds and Hargreaves thermal sensitivity and can be attenuated by administering drugs such as gabapentin, a first-line analgesic for neuropathic pain.
Ideal group sizes are>10 animals.