Open Field Activity
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
The open field test is a useful tool for assessing locomotor, psychological and other sensorimotor behavior in rodents. An automated system is in place that is capable of monitoring multiple locomotor and psychotherapeutic related parameters. Open field assessments are useful for determining how a drug affects not only normal locomotion, but other activities including exploratory behavior, stereotypic activity, rearing and time spent in pre-defined zones within the chamber. The chamber can be modified to examine anxiety-related behaviors, learning and memory functions and place-preference assays for addiction. Like the Irwin Observational Battery of tests, the open field test can be used in conjunction with many of the assays within the Melior theraTRACE® platform.
The study summarized below illustrates how CNS-active drugs alter open field test activity in mice. First, MK-801, an NMDA antagonist, yields a dose-dependent increase in locomotor activity. Then, risperidone, a catecholamine antagonist, in combination with MK-801, blocks the hyper-locomotor activity otherwise caused by MK-801.
Part I: MK-801 induced hyperactivity