Spasticity: Straub Tail Reaction
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Spasticity is defined as a muscle tone disorder characterized by hyperactive tonic stretch reflexes. To relieve abnormally increased muscle tone in patients suffering from painful muscle spasms, the centrally acting muscle relaxants are used (baclofen, tizanidine, mephenesin, memantine). Morphine-induced Straub tail reaction is expressed as a tonic dorsal extension of the tail and may reflect drug-induced transient spasticity. This test has been used to evaluate the effect of centrally acting muscle relaxants. We established the utility of the morphine-induced Straub test reaction for detecting potential anti-spasticity effects of compounds. The results point at the Straub tail response as a useful tool for in vivo screen of candidate compounds for CNS trauma and spasticity.
Reference: Belozertseva et al. Morphine-induced Straub tail reaction in mice treated with serotonergic compounds. Eur J Pharmacol. 2016 Nov 15;791:1-7. doi: 10.1016/j.ejphar.2016.08.014. Epub 2016 Aug 24