DEXA Body Composition Scan
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Obesity is a condition of pandemic proportions in the modern world. A myriad of conditions ranging from cardiovascular disease, type-2 diabetes, cancer, and even depression have been linked to obesity (Bloom SR, 2008).
Research into the mechanisms and treatment of obesity is an ongoing area of interest to many in the pharmaceutical and academic communities. Animal models have proven useful in studying the effects of compounds on diet-induced obesity (DIO) (Hildebrand AL, 2003; Levin BE, 2000).
Dual-energy Xray absorptiometry (DEXA) is an instrument that uses X-rays with different wavelengths to quantitate a number of parameters associated with overall body composition such as bone mineral density, bone mass, lean tissue mass, fat tissue mass, and others.
In this study we used a high-fat diet induced obesity mouse model to illustrate the use of DEXA. Fat mass (adipose tissue) and lean mass (largely muscle) were assessed using DEXA in both standard and high-fat diet fed mice. At Melior, this assay serves as a platform for a number of additional acute and chronic disorders consistent with diet-induced obesity changes in humans.