Insulin Tolerance Test (ITT)
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
The Insulin Tolerance Test (ITT) is designed to determine the whole body sensitivity of insulin receptors by measuring blood glucose levels changes before and after insulin administration. This is a standard test to determine the insulin resistance status in humans and experimental animals. This test is used to assess the insulin-sensitizing efficacy of test compounds and pharmacological agents that can modify insulin sensitivity.
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MLR-1023 is a potential “next-generation” insulin sensitizer that works independently of a PPAR mechanism by activating Lyn kinase. For more information on MLR-1023, please visit our sister site, Melior Pharmaceuticals.
Frequently Asked Questions
Subcutaneous injection (SC)
Yes. The customized time points can be applied to the protocol.
Blood (<5 µL) will be acquired from a tail snip and directly applied to a glucose test strip. The blood glucose value will be read by a pre-calibrated glucometer.
Synonyms: ITT, insulin tolerance, insulin sensitivity, insulin resistance