Acute Nephritis Model
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Nephritis can be modeled in rats with an intraperitoneal injection of the chemotherapeutic agent Cisplatin.
Acute nephritis is characterized by altered blood and urine chemistries, as well as histological evidence of kidney tubule damage and inflammatory cell infiltration. Pre-treatment with DL-propargylclycine (PAG) has been suggested to reduce these markers of injury.
In this study, PAG was tested for effects on Cisplatin-induced changes in blood and urine chemistries, along with histological examination of kidney tissue after treatment.
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