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Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic erosive inflammation in joints leading to the destruction of cartilage and bone.
Immunization of mice with type II collagen leads to the development of arthritis in the collagen induced arthritis model of RA (CIA). A number of anti-inflammatory compounds are effective in reducing inflammation in this model of arthritis.
This study was designed to establish a collagen induced arthritis model of RA and test the efficacy of the anti-inflammatory reference compound, Dexamethasone, in the CIA model of RA.
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