Zymosan - A Induced Acute Peritonitis Model
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Leukocyte infiltration into a site of injury or irritation is an integral part of an inflammatory process associated with the peritonitis response. The peritonitis model described below utilizes Zymosan-A to induce leukocyte accumulation in the peritoneum. This model can be utilized as a model of inflammation, acute peritonitis and polymorphonucleocyte migration. Importantly, this model is an effective for detecting a test compound’s ability to attenuate inflammatory processes associated with peritonitis. Anti-inflammatory agents including steroidal and non-steroidal anti-inflammatory compounds are effective in reducing leukocyte recruitment and/or infiltration in this model. In the study described below, leukocyte infiltration was induced by intraperitoneal administration of Zymosan-A and the responsiveness of this model to the steroid prednisone was measured. This study validates the use of this model for detecting compounds that are potential therapeutics for peritonitis
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The zymosan induced peritonitis model is typically run in an acute setting, performed in a single day with a single administration of test article. As a model of peritonitis it is similar to the Monocyte Infiltration model.