Acute Pancreatitis Model
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Multiple injections of Caerulein in mice caused significant acute pancreatitis, as measured by increases in serum amylase and pancreatic MPO. The Caerulein dosing was well-tolerated, with no observable adverse effects. Pre-treatment with PAG significantly reduced levels of MPO, but did not alter amylase levels in the challenge model.
These results demonstrated that Caerulein injections are sufficient to induce a measurable acute pancreatitis model that can be moderately altered by PAG pre-treatment. This model has potential utility in screening therapeutic compounds for treatment of pancreatitis.
Frequently Asked Questions
The endpoints that are most often performed is MPO and serum amylase levels analysis.
We have recently validated a chronic pancreatitis model where caerulein was administered three days a week for 28 days. We saw significant changes in the histology of the pancreas. Our scientists would be more than happy to provide the validation data for this chronic pancreatitis model.
Yes. We also have an acute pancreatitis induced by the administration of IL-12 and IL-18 in ob/ob mice. Our scientist would be more than happy to provide the validation data for this acute pancreatitis model.
Synonyms: Pancreatic Inflammation, MPO, Amylase