Bioanalysis

Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic

Bioanalysis capabilities allow for quantitation of small molecule concentrations (e.g. drug levels) in biological samples (e.g. blood) using HPLC with tandem mass spectroscopy (LC/MS/MS). Several samples types are handled including brain (whole, dissected brain regions, punches), whole blood or plasma, CSF, peripheral organs.

Melior Discovery offers bioanalysis services in collaboration with our partner, Keystone Bioanalytical (North Wales, PA). Melior has been working with Keystone since our inception in 2005. They are our chosen partner because of their high reliability, fast turn around, and reasonable cost.

Melior works with Keystone as a subcontracted service to provide the bioanalytical components of a study in a turnkey solution to our clients. All bioanalytical data is integrated into our final study reports.

Applications:

Pharmacokinetic studies
Drug exposure
Brain neurochemistry
Measurement of exogenous compounds
Measurement of drug metabolites

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This model is 1 of more than 60 models included in our theraTRACE^® platform

Ready to get started or looking for a custom model?

Contact us today for more information about our bespoke research models and to discuss how we can help you answer your unique research questions.

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Frequently Asked Questions

Do you have the ability to perform the LC/MS/MS analysis?

Yes. We work closely with Keystone Bioanalytical who has the ability to analyze blood and other tissue samples.

Can bioanalysis be performed as part of a larger study?

Yes. Terminal collection of plasma, serum, whole blood, or other tissues can be performed and be sent for bioanalysis. Alternatively, blood or tissue can be collected at specific timepoints for analysis. Our scientists would be more than happy to discuss the feasibility of perform bioanalysis within a larger study.

Synonyms: PK, Pharmacodynamics, Pharmacokinetics

Interested in running a Bioanalysis study?

If you are interested in learning more about the Bioanalysis, please contact us to start the conversation today!

Discuss your project with us

We chose Melior Discovery because they were responsive and cost effective. We are staying with them as a chosen scientific partner because of their thoughtful scientific input to experimental design and attention to detail. Their expertise and flexibility allowed us to quickly adapt the study design and evaluate additional outcome measures to pursue unexpected activity.
Sridharan Rajamani, Ph.D., Senior Research Scientist
Gilead Sciences
I have been working with Melior on a number of projects over the course of a few years now. They have been a great partner throughout this time. The scientists whom I have worked with have been great problem-solvers and were customer focused
Jay Lichter
Avalon Ventures
[We] have been impressed with [Melior’s] ability to rapidly and effectively evaluate compounds in animal models…as we strive to identify compounds to ameliorate the devastating symptoms of Rett,
Monica Coenraads, Executive Director
Rett Syndrome Research Trust
Melior is more than just a service company. Their experienced staff guided us in our drug development efforts. We consider Melior an extension of our own research team.
Josh Schultz
Carolus Therapeutics
Addex Therapeutics has been collaborating with Melior Discovery for more than a year. The studies performed at Melior are always carefully planned and skilfully executed while the progress of the project is well-tracked and communicated to the customer. On several occasions, when testing our compounds in a new in vivo assay, we relied on Melior's scientists in their guidance and advice. We have been particularly pleased with a series of experiments involving assessment of compounds' profiles in the rat sleep/wake EEG. This approach, that has a translational relevance, offered a sensitive measure of a compound's efficacy and side-effects
Mikhail Kalinichev, Ph.D., Associate Research Director
Addex Therapeutics
Having worked with Melior quite extensively over the past several years, we find the team to be highly knowledgeable, responsive and adaptable to our needs. The overall process has been highly efficient and we are impressed by the quality of their reports
Christopher Prior, Ph.D., CEO,
PhaseBio Pharmaceuticals Inc.
…to evaluate our lead compound in an EEG-based sleep wake model. Melior’s very experienced team provided valuable insights and recommendations on study design, analysis and interpretation of the data. As a virtual company, Prexa relied on Melior to become an extension of our knowledge team and they met all our expectations
Pat Baskin and Ev Graham
Prexa Pharmaceuticals
State of-the-art Preclinical Pharmacology
Melior provided State-of-the-art Preclinical Pharmacology Support for a period of nearly a year where a series of in vivo studies were completed on a weekly basis. The staff was extremely user-friendly and the operational processes were excellent. I can recommend Melior without reservation.
Richard DiMarchi, PhD
Cox Professor of Chemistry & Gil Chair in Biomolecular Sciences Indiana University, Department of Chemistry