Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Pharmacology is the study of the interactions between drugs and the living organism. The two divisions of pharmacology are pharmacokinetics and pharmacodynamics.
Pharmacokinetics (PK) refers to the movement of drugs through the body (adsorption, distribution, excretion and metabolism). Pharmacodynamics (PD) refers to the body’s biological response to drugs (behavior, receptor occupancy, qEEG and other biomarkers).
Melior customarily accompanies many of it animal model studies with PK analysis in order to get a more complete picture of the PK-PD relationship. Melior provides studies to address all aspects of PK and PD, including in vivo dosing via all routes, tissue and blood/plasma collection, bioanalysis, non-GLP noncompartmental analyses
These studies are useful for
- Drug exposure
- Pharmacokinetic modelling
- Prediction of dose requirements (PK/PD)
- Assess bioavailability/bioequivalence
The figure below illustrates the summary output of a typical PK study in mice with a test article.
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Frequently Asked Questions
Yes. We work closely with a bioanalytical lab that has the ability to analyze blood and other tissue samples.
We think a PK analysis should be performed prior or in conjunction with any other study. Understanding how test articles are distributed and how long the compounds remains within the body is important for determining the route of administration and frequency of dosing.
Yes. The customized time points can be applied to the protocol.
Synonyms: PK, ADME, Pharmacodynamics