Allergic Contact Hypersensitivity
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Contact hypersensitivity models mimic contact dermatitis aspects of immune function. Many cutaneous disorders are characterized by inflammation involving different immune signalling pathways. Accordingly there are variances of contact hypersensitivity animal models of atopic dermatitis that use different haptens to activate different immune pathways.
The immune reaction induced by the method described below is regarded as an atopic dermatitis mouse model. It is associated with epidermal swelling at the site of challenge. Melior has established models of allergic contact dermatitis hypersensitivity using oxazolone, DNFB and other haptens which vary in the degree to which they involve Th1 versus Th2 pathways. The localized inflammatory responses can be attenuated by corticosteroids and topical agents used to treat atopic dermatitis.
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As described above this is typically run as a 1 week model and typically involves groups sizes on the order of 8 to 10 mice depending upon effect size expected for a test article. Most commonly test articles are administered acutely (one time).