C-fiber Pain Reflex
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C-fibers are small unmyelinated fibers transmitting diffuse pain signals from the periphery to the spinal cord. Larger and faster myelinated A∂ & Aβ fibers transmit pain and touch information.
C-fiber pain activity can be selectively evaluated by stimulating the footpad and recording reflex activity in the peroneal muscle between 150 and 400 msec following the stimulus. Activity in this pathway can be recorded for several hours allowing within-animal determination of baseline, test article, and drug interaction effects.