Motor Evoked Potentials
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Nerve conduction and/or neuromuscular function following drug treatment, injury, or as a function of genetic factors can be evaluated in a variety of ways. Stimulation of the sciatic nerve at the hip produces compound motor action potential (CMAP) responses in the plantar foot muscle that are delayed and reduced in amplitude in SOD (superoxide dismutase) knockout (SOD -/-) or transgenic (G93A) mice. Mice can be evaluated as early as 5 weeks of age and can be tested weekly or biweekly.
Motor evoked potential monitoring can be studied in either mice or rats and can be incorporated a a longitudinal endpoint for tracking a variety of progressive conditions as illustrated above.