DSS-Induced Model of Colitis
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Inflammatory bowel disorders (IBD), including colitis, are destructive diseases.
In this model, IBD is induced through administration of dextran sodium sulfate (DSS) in the drinking water of mice. This results in epithelial damage and a robust inflammatory response in the colon lasting several days. Rodents that are treated with DSS develop inflammation of the colon, exhibit diarrhea, rectal bleeding and weight loss. At Melior, we have established a chronic model of DSS-induced colitis.
Ready to get started or looking for a custom model?
Contact us today for more information about our bespoke research models and to discuss how we can help you answer your unique research questions.
Frequently Asked Questions
Colon length and colon weight/length ratio are commonly used endpoints. Histology and histopathology can also be added to understand the histological changes the colon undergoes during the model.
Dextran sulfate sodium (DSS) is a sulfated polysaccharide with variable molecular weights. Administration of DSS causes human ulcerative colitis-like pathologies due to its toxicity to colonic epithelial cells, which results in compromised mucosal barrier function. Clinical observations similar to human pathologies, such as weight loss, diarrhea and occult blood in stool are commonly observed in the DSS model.
Synonyms: IBS, colitis, Inflammatory Bowel Disease, IBD