Gastrointestinal Transit Model
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Drug-related gastrointestinal side effects can cause a great deal of discomfort and pain. These side effects include constipation, GI irritation, abdominal constriction or diarrhea.
Similar to the Colonic Propulsion Motility model, the Gastrointestinal Transit Model (sometimes call the Charcoal Meal Model) is also commonly used to evaluate bowel motility and further reflect GI function.
At Melior, we have validated this model by examining an opioid’s effect on inhibiting gastrointestinal motility.
Like other GI motility models the Gastrointestinal Transit model, is typically a one-day model evaluating acute effects of test articles (a single administration). It has relatively low variability typically yielding statistically significant effects with group sizes of 6 to 8 animals. It works well in both rats and mice.