6-Hz Psychomotor Seizure
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Epilepsy is a significant medical problem facing millions of people, most of who are not controlled by the current anticonvulsants on the market. Although a number of marketed anticonvulsant agents exist, there remains a high unmet medical need for better agents with reduced liability.
The 6 Hz Seizure Model is categorized as a partial or focal form of seizure (Psychomotor Seizure). This Psychomotor Seizure procedure is a model that tests a compound’s efficacy on the inhibition of certain forms of seizure. When characterizing anti-seizure candidates it an excellent screening complement to models of generalized seizure such as PTZ or MES.
In the current model, the effects of Valproate (100 and 300 mg/kg) as an anticonvulsant were tested against vehicle treated mice at differing currents of 22, 32 or 44 mA. The percentage of mice exhibiting seizure was examined.
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Barton ME, Klein BD, Wolf HH, White HS. (2001) Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res. 47(3):217-27.
Kaminski RM, Livingood MR, Rogawski MA (2004). Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia. 45(7):864-7