6-Hz Psychomotor Seizure
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Epilepsy is a significant medical problem facing millions of people, most of who are not controlled by the current anticonvulsants on the market. Although a number of marketed anticonvulsant agents exist, there remains a high unmet medical need for better agents with reduced liability.
The 6 Hz Seizure Model is categorized as a partial or focal form of seizure (Psychomotor Seizure). This Psychomotor Seizure procedure is a model that tests a compound’s efficacy on the inhibition of certain forms of seizure. When characterizing anti-seizure candidates it an excellent screening complement to models of generalized seizure such as PTZ or MES.
In the current model, the effects of Valproate (100 and 300 mg/kg) as an anticonvulsant were tested against vehicle treated mice at differing currents of 22, 32 or 44 mA. The percentage of mice exhibiting seizure was examined.
Barton ME, Klein BD, Wolf HH, White HS. (2001) Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res. 47(3):217-27.
Kaminski RM, Livingood MR, Rogawski MA (2004). Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia. 45(7):864-7