Maximal Electroshock (MES)
Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic
Epilepsy is a significant medical problem facing millions of people, most of who are not controlled by the current anticonvulsants on the market. Although several marketed anticonvulsants exist there remains a significant unmet medical need for better anticonvulsants with reduced liability.
Amongst all animal models of seizure and epilepsy, the maximal electroshock (MES) model is categorized as a model of generalized tonic-clonic seizure. When screening anticonvulsant candidates the MES model is an excellent tool for evaluating anti-seizure characteristics compared to a focal or partial seizure model (Psychomotor Seizure) such as the 6 Hz Model.
In the study described below, the effects of Phenytoin at various dose levels of 3, 10, 30 and 60 mg/kg were compared to vehicle treated mice. Animals were treated with either vehicle or Phenytoin and observed for 60 minutes prior to MES.