Dr. Shamroop Mallela

Senior Scientist

Dr. Mallela, a Senior Scientist at Melior Discovery, boasts over 7 years of extensive experience in both in vitro and in vivo preclinical research. With a notable track record, he has authored more than 20 peer-reviewed articles and contributed to 2 book chapters.

Dr. Mallela earned his Ph.D. in biochemistry from the University of Fribourg, Switzerland. During this period, his research focused on identifying new ceramide synthase paralogues crucial in the sphingolipid signaling pathways, which are well-established as pivotal players in various diseases, including cancer, cardiovascular ailments, metabolic disorders, liver diseases, nephrological issues, and neurological conditions. He earned a master’s degree in biotechnology from Bharathiar University, India, receiving a gold medal for his outstanding academic performance.

Before joining Melior Discovery, Dr. Mallela served as a postdoctoral research associate at the Miller School of Medicine, University of Miami, USA. His exceptional work during this time led to the prestigious American Diabetes Association (ADA) postdoctoral fellowship. His research in this role encompassed investigations into kidney diseases, both type I and type II diabetes, Alport syndrome, high content imaging for drug discovery, as well as the characterization of transgenic mice for the development of kidney disease models. Subsequently, he transitioned to Cardio-lab, where he delved into research on cardiovascular diseases, oncology, and obesity utilizing various preclinical rodent models.

Dr. Mallela possesses a wealth of expertise in a wide range of cellular, molecular, and immunological techniques. These skills include DNA, RNA, protein, and lipid extraction from cells and tissues, conducting apoptosis, viability, and cytotoxicity assays, performing ELISA assays, cloning, immunoprecipitation, immunofluorescence, immunohistochemistry, immunocytochemistry, Western blotting, qRT-PCR, FACS/Flow cytometry, microscopic imaging using fluorescent and confocal microscopes, tumor implantation, tumor size measurement, and conducting necropsies.

Beyond his professional endeavors at Melior, Dr. Mallela finds great joy in spending quality time with his family and friends. He likes to participate in the culinary process, delights in listening to music, and enjoys watching movies as well.

We chose Melior Discovery because they were responsive and cost effective. We are staying with them as a chosen scientific partner because of their thoughtful scientific input to experimental design and attention to detail. Their expertise and flexibility allowed us to quickly adapt the study design and evaluate additional outcome measures to pursue unexpected activity.
Sridharan Rajamani, Ph.D., Senior Research Scientist
Gilead Sciences
I have been working with Melior on a number of projects over the course of a few years now. They have been a great partner throughout this time. The scientists whom I have worked with have been great problem-solvers and were customer focused
Jay Lichter
Avalon Ventures
[We] have been impressed with [Melior’s] ability to rapidly and effectively evaluate compounds in animal models…as we strive to identify compounds to ameliorate the devastating symptoms of Rett,
Monica Coenraads, Executive Director
Rett Syndrome Research Trust
Melior is more than just a service company. Their experienced staff guided us in our drug development efforts. We consider Melior an extension of our own research team.
Josh Schultz
Carolus Therapeutics
Addex Therapeutics has been collaborating with Melior Discovery for more than a year. The studies performed at Melior are always carefully planned and skilfully executed while the progress of the project is well-tracked and communicated to the customer. On several occasions, when testing our compounds in a new in vivo assay, we relied on Melior's scientists in their guidance and advice. We have been particularly pleased with a series of experiments involving assessment of compounds' profiles in the rat sleep/wake EEG. This approach, that has a translational relevance, offered a sensitive measure of a compound's efficacy and side-effects
Mikhail Kalinichev, Ph.D., Associate Research Director
Addex Therapeutics
Having worked with Melior quite extensively over the past several years, we find the team to be highly knowledgeable, responsive and adaptable to our needs. The overall process has been highly efficient and we are impressed by the quality of their reports
Christopher Prior, Ph.D., CEO,
PhaseBio Pharmaceuticals Inc.
…to evaluate our lead compound in an EEG-based sleep wake model. Melior’s very experienced team provided valuable insights and recommendations on study design, analysis and interpretation of the data. As a virtual company, Prexa relied on Melior to become an extension of our knowledge team and they met all our expectations
Pat Baskin and Ev Graham
Prexa Pharmaceuticals
State of-the-art Preclinical Pharmacology
Melior provided State-of-the-art Preclinical Pharmacology Support for a period of nearly a year where a series of in vivo studies were completed on a weekly basis. The staff was extremely user-friendly and the operational processes were excellent. I can recommend Melior without reservation.
Richard DiMarchi, PhD
Cox Professor of Chemistry & Gil Chair in Biomolecular Sciences Indiana University, Department of Chemistry