Dr. Shamroop Mallela

Senior Scientist

Dr. Mallela, a Senior Scientist at Melior Discovery, boasts over 7 years of extensive experience in both in vitro and in vivo preclinical research. With a notable track record, he has authored more than 20 peer-reviewed articles and contributed to 2 book chapters.

Dr. Mallela earned his Ph.D. in biochemistry from the University of Fribourg, Switzerland. During this period, his research focused on identifying new ceramide synthase paralogues crucial in the sphingolipid signaling pathways, which are well-established as pivotal players in various diseases, including cancer, cardiovascular ailments, metabolic disorders, liver diseases, nephrological issues, and neurological conditions. He earned a master’s degree in biotechnology from Bharathiar University, India, receiving a gold medal for his outstanding academic performance.

Before joining Melior Discovery, Dr. Mallela served as a postdoctoral research associate at the Miller School of Medicine, University of Miami, USA. His exceptional work during this time led to the prestigious American Diabetes Association (ADA) postdoctoral fellowship. His research in this role encompassed investigations into kidney diseases, both type I and type II diabetes, Alport syndrome, high content imaging for drug discovery, as well as the characterization of transgenic mice for the development of kidney disease models. Subsequently, he transitioned to Cardio-lab, where he delved into research on cardiovascular diseases, oncology, and obesity utilizing various preclinical rodent models.

Dr. Mallela possesses a wealth of expertise in a wide range of cellular, molecular, and immunological techniques. These skills include DNA, RNA, protein, and lipid extraction from cells and tissues, conducting apoptosis, viability, and cytotoxicity assays, performing ELISA assays, cloning, immunoprecipitation, immunofluorescence, immunohistochemistry, immunocytochemistry, Western blotting, qRT-PCR, FACS/Flow cytometry, microscopic imaging using fluorescent and confocal microscopes, tumor implantation, tumor size measurement, and conducting necropsies.

Beyond his professional endeavors at Melior, Dr. Mallela finds great joy in spending quality time with his family and friends. He likes to participate in the culinary process, delights in listening to music, and enjoys watching movies as well.