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The chronic mild stress (CMS) model is a paradigm developed in animals to model the relatively minor and unanticipated irritants that lead to a state of anhedonia (an inability to experience pleasure) in some individuals.
Melior has developed a chronic mild stress paradigm that leads to increased behavioral depression and elevated corticosterone levels in rodents. Other parameters that can be evaluated in the CMS model include Coat Assessment, Hyperthermia, Sucrose Intake, and behavior modification such as seen in the Tail Suspension Test. These changes can be attenuated by treatment with an antidepressant.
The Chronic Mild Stress model is generally run over about a 4 – 5 month period. Due to the higher variability in evaluated parameters, ideal group sizes are >12 animals.